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Title : FORMULATION AND EVALUATION OF ORAL DISINTEGRATING RELEASE DOSAGE FORM CONTAINING MECLIZINE HCL
Authors : *Ramanjaneyulu M, M Shubash Kumar, Ravindar Bairam and P Mahesh Babu
Abstract : Orally  Disintegrating  Tablet  ( ODT )  is  a  solid  unit  dosage  form  containing  drugs  that disintegrates  rapidly  and  dissolves  in  the  mouth  without  taking  water  within  60seconds   or  less. Hence ,  in  the  present  study  an  attempt  made  to  formulate  and evaluate the oral dissolving   tablets   of   Meclizine   Hydrochloride  of  ( 25 mg )   oral   disintegrating  tablets containing  different  concentration  of  excipients  used  for  anti vertigo and  motion sickness. Microcrystalline  cellulose    selected   as  diluents ,  crosscarmellose  sodium ,  crosspovidone were  selected  as  super  disintetegrants. Magnesium stearate was used as a lubricant. Direct compression method was used to formulate the tablets.  All  the  formulations  shown  the acceptable  flow  properties  &  pre-compression  parameters  like   bulk  density,  tap  density, angle  of  repose. The  post  compression  parameters  like  hardness,  friability,  disintegration time,  wetting  time,  values  found  to  be  within   I.P. limits.  The  percentage content  of   all  tablets found  to  be  between  97.6  to  99.8  of  meclizine  hydrochloride  which  is within  the  limit.

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