View                 Download                 XML
Title : PREPARATION AND EVALUATION OF SOLID DISPERSIONS OF NIMESULIDE
Authors : *Swathi Gunturu and Divya Amaravadi
Abstract : Nimesulide is a non-steroidal anti-inflammatory drug. Here, the present study was planned to prepare and evaluate the solid dispersions of Nimesulide. Solid dispersions of Nimesulide were prepared by using various hydrophilic carriers like PVP K-40, PEG 4000, PEG-6000 in various ratios by solvent evaporation method. The solubility of Nimesulide in different solvents; water, acetone and ethanol was enhanced in the form of solid dispersions. The prepared solid dispersions were subjected to solubility studies (in water, 0.1 N HCL and phosphate buffer pH 7.4. Stability studies were carried out at 40±2° C and at 75±5 % RH. The phosphate buffer pH 7 Showed highest solubility for the drug. The cumulative amount of drug release of Nimesulide: PVP K-40 was 97.06 %; Nimesulide: PEG-4000 was 97.42%; Nimesulide: PEG -6000 was 97.46% respectively. Therefore it can be concluded that dissolution rate of poorly soluble drug (Nimesulide) can be significantly enhanced by formulating them into solid dispersions

A PHP Error was encountered

Severity: Notice

Message: Undefined index: HTTP_REFERER

Filename: views/issue_title.php

Line Number: 65

Backtrace:

File: /var/www/html/pharmascholars-com/app_psl/views/issue_title.php
Line: 65
Function: _error_handler

File: /var/www/html/pharmascholars-com/app_psl/controllers/PSL.php
Line: 144
Function: view

File: /var/www/html/pharmascholars-com/index.php
Line: 293
Function: require_once

">Back