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Title : NEW ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF GEMFIBROZIL IN BULK AND PHARMACEUTICAL FORMULATION BY RP-HPLC
Authors : *A. Sushma, K. Harinadha Babu and G. Vijay Kumar
Abstract : A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the determination Gemfibrozil in bulk and pharmaceutical dosage form. The column used was Agilent Zorbax C8 (150 ×4.6mm, 5µ) in gradient mode,   with mobile phase containing Solvent-A: phosphate buffer adjusted the pH-3.0 with orthophosphoric acid Solvent-B: Methanol the flow rate was 1.5 mL/ min and eluents was monitored at 276 nm. The retention time Gemfibrozil was 5.158 min, respectively. The linearity for Gemfibrozil was in the range of 30-450 µg/ml respectively. The recovery of Gemfibrozil was found to be 99.5%, respectively. The proposed method was validated and successfully applied to the estimation of Gemfibrozil in capsule dosage form

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