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Title : SYNTHESIS AND PRELIMINARY EVALUATION OF NOVEL 1, 5-BENZOTHIAZEPINE DERIVATIVES AS ANTI-LUNG CANCER AGENTS
Authors : *K. L. Ameta, Nitu S. Rathore and Biresh Kumar
Abstract : A series of novel 1, 5-benzothiazepine derivatives having a biologically active thiazepine moiety was synthesized by the condensation of substituted chalcones with 2-aminothiophenol using conventional as well as non-conventional methods. The structures of the newly synthesized compounds were confirmed by FTIR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against human lung cancer cell line (A549) using Adriamycin as a reference drug.

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