||Pulmonary hypertension is a progressive symptomatic fatal disease. It is a diagnosis of exclusion. The main goal of therapy is to lower pulmonary arterial pressure and pulmonary vascular resistance while preserving systemic pressure. Current treatments including calcium channel blockers, endothelin-1 antagonists, prostanoids, phosphodiesterase inhibitors, and prostacyclins. These treatments are palliative, may slow the progression of the disease, relief symptoms, and improve quality of life, but do not cure it. The article reviews the current updated therapeutic treatment, pharmacological action, doses, and adverse drug reaction.