||Khamira Gaozaban ambri jadwar ood salib wala (KGA) is a traditional medicine in Southeast Asia, used as anxiolytic, antiepileptic and nervine tonic. We have evaluated its role as an anti-depressant agent in animal models of stress. We evaluated an anti-depressant activity by forced swim and marble burying method. 96 NMRI mice were randomly divided into Control group which received saline, a standard group which received Imipramine and two test groups which were given two doses 86 mg/kg and 170 mg/kg doses of KGA with different models of treatments. Each group consisted of 6 animals irrespective of sex. Results show pronounce anti-depressant effect both in acute (One day) and sub-acute (10 days) treatment with CMS (chronic mild stress) model and one day and 15 day treatments in marble burying test. Concluding results suggest strong anti-depressant activity of KGA in different treatment patterns.