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Title : METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ESTIMATION OF ROSUVASTATIN AND OLMESARTAN IN BULK AND TABLET DOSAGE FORM BY RP-HPLC
Authors : *Elijabeth.Y, Ramesh.B, K.Dhanalaxmi, Nagarjuna reddy
Abstract : A simple, precise, accurate and rapid reverse phase high performance liquid chromatographic new method had been developed for simultaneous estimation of Rosuvastatin and Olmesartan in bulk and tablet dosage form. An Agilent XDB, C18 column having I’d of 150×4.6 mm and 5µm particle size was used. The new method was carried out in gradient program using mobile phase, 0.01M Potassium Dehydrogenate orthophosphate: acetonitrile (55:45 v/v) adjusted to pH-3.2 using dilute ortho phosphoric acid. Flow rate was adjusted to 1.0ml/min and effluents were monitored at 240nm. The retention time obtained for Rosuvastatin and Olmesartan was 2.61 and 5.13min respectively. The calibration curves were linear in the concentration range of 10-30µg/ml for Rosuvastatin and 50-150µg/ml for Olmesartan. The developed method was validated in accordance to ICH guidelines.

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