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Title : FORMULATION AND CHARECTERIZATION OF IN SITU IMPALNT OF OCTREOTIDE ACETATE
Authors : *Prashanth P, Sumit Shah, Arvind G, Naveen Konda
Abstract : Octreotide is the acetate salt of a cyclic octapeptide. It is a long-acting octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. The peptide drugs after oral and parental administration the poor bioavailability in the blood due to their short biological half –lives caused by their metabolic instability. so that these peptide drugs are formulated by polymeric drug delivery systems such as micro particles or implants, has been proposed enabling their sustained  release after a residence time in the polymer which protects the peptide against enzymatic and hydrolytic influences of biological media. In the present study, In situ implants of Octreotide acetate were prepared by polymer precipitation method. PLGA is dissolved in hydrophilic solvents such as Dimethyl sulphoxide, N-Methyl 2-pyrrolidone, PEG-200 and Triacetin until the formation of a clear solution. Different formulations were prepared using different concentration of polymer i.e. 5to35 % w/w. The characterization of implant was carried out by Determination of PLGA 5050 polymer ratio by NMR, Determination of molecular weight of polymer by GPC, Viscosity of polymer solution, Sterility test, In-vitro drug release, Release kinetics and Scanning electron microscopy. The Maximum percent of drug release with minimum Initial Burst release was found in formulation (F3) with NMP as solvent. Effect of gamma irradiation on molecular weight of polymer, viscosity of polymer solution, monomer ratio of lactide and glycolide and in-vitro release after gamma radiation was studied with F3 formulation.

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