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Title : NOVEL SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF NATEGLINIDE IN PURE AND DOSAGE FORMS
Authors : *Ch. Sudheer, T.Tirumaleswara Rao, B.V.Sreenivasulu, C. Ramababu
Abstract : Two simple, sensitive and selective methods for the determination of Nateglinide in bulk and in pharmaceutical formulations were described. These methods are based on extraction of this drug into chloroform as ion-pair with basic dyes, Safranin O (SFNO) and Methylene blue (MB). The optimum conditions of the reactions of the developed methods were studied and optimized. The absorbance of the colored products was measured at 515nm for nateglinide-SFNO and 620nm for nateglinide-MB. The calibration curves obeyed the beer's law over the concentration range of 2.5-12.5μg/mL for nateglinide-SFNO and nateglinide-MB with correlation (r2=0.9997 & 0.9992) respectively. The results of analysis for the two methods have been validated statistically and by the recovery studies. The proposed methods were simple, sensitive and economical for the quantitative determination of nateglinide and were successfully employed for the assay in bulk and in formulations.

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