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Title : FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF VILDAGLIPTIN
Authors : *Vishnu P, Shireesh kiran R, Chaitanya B, Naveenbabu K, Vijayavani Ch. S.
Abstract : The purpose of this research work was to establish Vildagliptin sustained release matrix tablets of&nbsp; 50mg. Vildagliptin is an anti diabetic drug of the new dipeptidylpeptidase-4 (DPP-4) inhibitor class of drug. The tablets were prepared by wet granulation technique using different grades of Hydroxy Propyl Methyl cellulose (HPMC K 100 LV, HPMC K15M and HPMC K4M) as extended release polymer. Tablets were evaluated for different parameters such as thickness, hardness, friability, weight variation, in vitro dissolution studies and FT-IR studies. The physico-chemical property of the finished product compiles with the internal specification limits. In vitro release from the formulation was studied as per the USP and IP dissolution procedure. The formulation gave a release of 98.5 % for 24 hr and the data best fitted into Higuchi model.&nbsp; From the present study it was concluded that the vildagliptin sustained release tablets can extend drug release and improve the bioavailability of vildagliptin. <br />

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