||A simple, accurate, rapid, precise, specific and cost effective reverse phase high performance liquid chromatography (RP-HPLC) method have been developed and subsequently validated for simultaneous estimation of Aliskiren and Amlodipine in pharmaceutical dosage forms. Chromatography is carried out isocratically at 30°C ± 0.5°C on an Water’s X-bridge C-18 column (4.6 x 150mm, 5μ particle size) with a mobile phase composed of acetonitrile -phosphate buffer (pH-2.5) (40:60, v/v) at a flow rate of 1.0 mL/min. Detection was carried out using a PDA detector at 230 nm. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness are studied as reported in the International Conference on Harmonization guidelines. The retention times for Aliskiren and Amlodipine are 3.8 min and 5.1 min respectively. The linearity range for Aliskiren and Amlodipine are 18.75-187.5µg/ml and 1.25-12.5 µg/ml respectively. The correlation coefficients for both components are close to 1. The relative standard deviations for six replicate measurements of samples in tablets are always less than 2%.