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Title : FORMULATION AND EVALUATION OF LAMIVUDINE AND TENOFOVIR DISPROXIL FUMARATE IR TABLETS
Authors : *Patil Sagar Nanaji, Swati Shailendra Rawat, D. Yashwanth Kumar
Abstract : The main objective of the present study is to formulate and evaluate an immediate release tablet of Lamivudine and Tenofovir Disproxil Fumarate using different disintegrants. Lamivudine and Tenofovir Disproxil Fumarate belong to class of anti-retroviral drugs known as nucleotide analogue reverse transcriptase inhibitors. Pre formulation studies were performed prior to compression. The tablets were compressed using microcrystalline cellulose, crospovidone, crosscarmallosesodium, magnesium stearate and Aerosil. The fabricated tablets were evaluated for various micrometric properties like bulk density, tapped density, compressibility index, Hausner&rsquo;s ratio, angle of repose and post compression characteristics like thickness, hardness, friability, disintegration time and drug release. Crospovidone is found to be the better disintegrant when compared to crosscarmallosesodium in the formulation of immediate release tablets of Lamivudine and Tenofovir Disproxil Fumarate. The absorbance of Lamivudine and Tenofovir Disproxil Fumarate were screened in the UV region and the maximum absorbance was found to be 271 nm and 260nm respectively and this was used for UV analysis. Among the six different formulations developed F6 was found to be the best one with a drug release of 99.96% at the end of 30min. <br />

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