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Title : MICROANATOMICAL DEFORMATION AFTER PTZ INDUCED SEIZURE IN MICE BRAIN
Authors : *Pankaj Kalita, Manash Barthakur
Abstract : Seizure is an abnormal state of brain electrical activity. The causes of seizure are different but seizure can be induced artificially also. Present experiment was conducted on albino mice and seizure was induced by Pentamethyline tetrazole (PTZ). Duration of seizure was maintained more than half an hour. Mice were sacrificed by cervical dislocation and brain was removed. Brain was fixed in Carnoy’s fixatives and sectioned at 5 micron thickness. Histological slide was stained in H&E stain. Micro-anatomical deformation of brain was observed in treated animals. Simultaneously control group of mice was maintained in same laboratory conditioned. Loss of cellular architecture in the neocortex I remarkably observed.  Excitatory neurotransmitter overloaded in axon terminal may be responsible for neuronal degeneration.

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