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Title : INCIDENCES, SCREENING AND CHEMOTHERAPY OF BREAST CANCER
Authors : *Sheikh Abdul Khaliq, Syed Baqir S. Naqvi, Anab Fatima
Abstract : Retrospective study in different ethnic groups determines the burden and patterns of breast cancers during the last eight years reported in Oncology wards of hospitals of Karachi, Pakistan and compares the pharmacotherapy/chemotherapy used with international guidelines, develops strategies for screening and evidence based pharmacotherapy/chemotherapy of cases. Every single one male &amp; female case with histologically and cytologically established breast cancer was enrolled from January 2003 to December 2010. Data for all patients were collected retrospectively by patient&rsquo;s file &amp; charts, which represents the population of Karachi, Interior Sindh &amp; Balochistan. 847 female patients investigated for their diagnosis of cancer type, ethnicity, age &amp; gender. The statistical analysis was performed for mean, standard error &amp; proportions. Pharmacotherapy/Chemotherapy &amp; screening employed by the hospitals was compared with international guidelines and evidences. Proportionately major ethnic groups female diagnosed with breast cancer in total female cases was Sindhi (25%), Urdu Speaking (48%), Baloch (6%), Pukhtoon (5%), Punjabi (11%), Siraiki (1%), Minorities &amp; others (4%). Mean age at the time of diagnosis was 44.07&plusmn;12.37 years, SE&plusmn; 0.069. Screening strategies are implemented in &lt;10% targeted population, however pharmacotherapy/chemotherapy was comparable with international guidelines. The study reveals that breast cancer incidences are highest among Urdu Speaking (17%) and then Sindhis (9%). Rests of the ethnic groups are in the range of 2-4%. There is a need to implement the screening strategies more extensively to the small/basic/rural health care centers for early diagnosis of the disease and new treatments like monoclonal antibodies are making revolution in the management of breast cancer.<br /><br />

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