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Title : SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF RISPERIDONE IN PHARMACEUTICAL BULK AND DOSAGE FORMS
Authors : *Akachukwu I, Nwodo N.J and Mbah C. J
Abstract : A simple, accurate and sensitive spectrophotometric method for determination of Risperidone has been developed. The method was based on the charge – transfer complexation reaction of Risperidone with chloranilic acid to form a violet – coloured complex having absorption maximum at 500 nm. Different variables affecting the reaction conditions such as the concentration of chloranilic acid, reaction time, diluting solvents were studied and optimized. Under the optimal conditions, linear relationship with good correlation coefficient (0.9979) was found between absorbance and the concentrations of Risperidone in the range of 2 – 12 µg/ml. The assay limits of detection and quantitation were 0.979 and 2.97 µg/ml respectively. The precision of the method and the values of relative standard deviation never exceeded 1.19%. No interference could be observed from the excipients commonly present in dosage forms. The proposed method was successfully applied to the analysis of Risperidone in pure and pharmaceutical dosage forms with good accuracy and precision; the recovery percentage ranges from 99.02 to 101.88 ± 0.54 to 1.19%. The proposed spectrophotometric method gives accurate and reproducible results besides being much more sensitive than the British Pharmacopoeia method that uses a larger amount of Risperidone.

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