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Title : ANTI-INFLAMMATORY ACTIVITY OF SOME NEWLY SYNTHESIZED CHALCONES
Authors : *Jahirul Islam Talukdar, Monica Kachroo and Rema Razdan
Abstract : A new series of chalcones have been synthesized by Claisen-Schmidt condensation of appropriate acetophenones like N-(4-acetyl-phenyl)-4-methoxy-benzamide [which is synthesized by reacting 4-methoxy-benzoyl chloride with 4-amino acetophenone] and N-(4-acetyl-phenyl)-4-chloro-benzamide, [which is synthesized by reacting 4-chloro-benzoyl chloride with 4-amino acetophenone]&nbsp; with various aldehydes&nbsp; in ethanolic KOH solution. The synthesized compounds were characterized using melting point, TLC, UV, IR, 1HNMR, 13C-NMR and CHN analysis. The compounds were evaluated for their anti-inflammatory activity by bovin serum albumin assay method ( in vitro ) and carrageenan induced rat paw oedema method ( in vivo ). Among the compounds synthesized, 2, 4-dimethoxy phenyl and 4-ethoxy phenyl derivative exhibited significant anti-inflammatory activity.<br /><br />

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