||A validated simple, sensitive, specific and precise RP-HPLC method was developed for the determination of Etravirine in pure and pharmaceutical formulations. Method was carried on Hypersil BDS C18 column (150 mm x 4.6 mm, 5 μ particle size) using phosphate buffer:acetontrile (35:65 v/v) as mobile phase. Detection was carried out by UV at 322 nm. The proposed method obeyed linearity in the range of 20-150 μg/mL and met all specifications as per ICH guidelines. Statistical analysis revealed that this method can be used in routine quality control studies of Etravirine in pure and its pharmaceutical formulations.