||A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination Paracetamol and Tapentadol HCl in pharmaceutical dosage form. The column used was Symmetry C18 (4.6 x 150mm, 5m) in isocratic mode, with mobile phase containing phosphate buffer-acetonitrile (50:50 v/v) adjusted to pH 3.6 with ortho phosphoric acid. The flow rate was 0.8 mL/ min and effluents were monitored at 243 nm. The retention times of Paracetamol and Tapentadol HCl were found to be 2.206 min and 3.807 min, respectively. The linearity for Paracetamol and Tapentadol HCl were in the range of 100-200 mcg/mL and 15-30 mcg/mL respectively. The recoveries of Paracetamol and Tapentadol Hcl were found to be 98.5% and 98.5%, respectively. The proposed method was validated and successfully applied to the estimation of Paracetamol and Tapentadol Hcl in combined tablet dosage forms.