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Title : ANTIDIARRHEAL ACTIVITY OF LEAVES EXTRACT OF MICROCOS PANICULATA LINN IN MICE
Authors : *Md. Masudur Rahman, Abu Mohammed Taufiqual Islam, Md. Ashraf Uddin Chowdhury, Muhammad Erfan Uddin and Ahsan Jamil
Abstract : The experiment of methanolic extract of Microcos paniculata leaves showed significant (p<0.001) inhibitor activity against castor oil induced diarrhea and castor oil induced enteropooling in mice at dose of 400 mg/kg body weight. There was also significant (p<0.01) reduction in gastrointestinal motility in the charcoal meal test. Loperamide (5 mg/kg b. wt) was used as positive control. These results revealed that the leaves extract possess pharmacological activity against diarrhea and may possibly explain the use of the plant in traditional medicine.

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