||The herbal medicines derived from various plants extracts are being increasingly utilized to treat a wide variety of clinical diseases1. Besides their action as gastroprotectives, flavonoids also act in healing of gastric ulcers2. The study was designed to investigate the anti-ulcer effect of chloroform extract of Chrozophora plicata leaves (600mg/kg) against experimentally induced ulcer models in albino rats. In the present study, anti-ulcer activity was assessed by using pylorus ligation induced and indomethacin (40mg/kg) induced Ulcer 3models in albino rats. The antiulcer activity was assessed by determining and comparing gastric volume, acidity, ulcer score and ulcer index in control, test extract and standard (ranitidine 10mg/kg) treated rats by using both pylorus ligation and indomethacin induced ulcer models. Pre-treatment of animals with the Chloroform extract of Chrozophora plicata (600mg/kg)) orally significantly reduced formation of ulcers induced by pylorus ligation and indomethacin models. The percentage inhibitions of ulcer with test extract being 60 ±1.12 % and 57.18 ± 1.32 % respectively whereas standard ranitidine has shown percentage inhibitions of ulcer to an extent of 100± 0.42% and 68.52±1.07% in both ulcer models. It is evident from literature that Chrozophora plicata leaves possess flavonoids4. The results obtained indicate that Chrozophora plicata possesses antiulcer principles.