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Title : THE BENEFICIAL ROLE OF NATURAL POLYPHENOLIC COMPOUNDS AS ANTIOXIDANTS IN ALZHEIMER DISEASE: BIOLOGICAL ACTIONS AND MECHANISMS UNDERPINNING THEIR BENEFICIAL EFFECTS
Authors : *Bisht Neha, Kumar Arun, Kothiyal Preeti
Abstract : Oxidative stress has been strongly implicated in the pathophysiology of neurodegenerative disorders such as Alzheimer&rsquo;s disease (AD). Mitochondrion is a key player that produces reactive oxygen species (ROS). Mitochondrial dysfunction found in AD patients may amplify the generation of ROS and oxidative stress. Increased ROS can cause damage to protein, lipid and nucleic acids. In recent years, antioxidants- especially those of dietary origin have been suggested as possible agents useful for the prevention and treatment of AD. Continuing research highlights the dynamic capacity of natural polyphenolic compounds to exhibit their antioxidant effect by a number of potential mechanisms. The free radical scavenging, in which the polyphenols can break the free radical chain reaction, as well as suppression of the free radical formation by regulation of enzyme activity or chelating metal ions involved in free radical production. Thus, the antioxidant properties certainly contribute to their neuroprotective effect. This article reviews the role of oxidative stress and the contribution of free radicals in the development of AD, and also discusses antioxidant effects of natural polyphenolic compounds such as green tea catechins, curcumin, resveratrol and their intracellular targets focusing on neuroprotective strategies for AD. <br />

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