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Title : INFLUENCE OF MULTIDRUG RESISTANCE PROTEIN-2 GENETIC POLYMORPHISM ON THE PHARMACOKINETICS OF MYCOPHENOLATE MOFETIL IN THAI KIDNEY TRANSPLANT PATIENTS
Authors : *Wanarat Anusornsangiam, Duangchit Panomvana, Kearkiat Praditpornsilpa,Amnart Chaiprasert, Surat Thungpanit
Abstract : The objective of this study was to investigate the influence of multidrug resistance protein (MRP), MRP-2 -24C>T polymorphism on the pharmacokinetics of mycophenolate mofetil in 118 Thai kidney transplant patients. The patients with MRP-2 -24C>T variant had a predicted area under the concentration-time curve (AUC 0-12 hr) of mycophenolic acid (MPA) significantly lower than the patients with wild-type gene (5.04 versus 5.92 mg x h/L/kg/mg dose, respectively, p-value = 0.008). In addition, the oral clearance of MPA in the patients with MRP-2   -24C>T variant was significantly higher than that of MPA in the patients with wild-type gene (0.15 versus 0.12 L/h/kg, respectively, p-value = 0.025). Therefore, this single nucleotide polymorphism (SNP) reduced MPA exposure and might lead to inferior immunosuppressive effect and eventually loss of clinical outcomes of immunosuppressive drug in Thai kidney transplant patients.

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