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Title : PHYTOCHEMICAL SCREENING, ANTI OXIDANT POTENTIAL AND ANTI INFLAMMATORY ACTIVITY OF LEUCAS DIFFUSA PLANT EXTRACT
Authors : *Ramachandran Somasundaram, Priyanka Vaddadi, Dhanaraju Magharla Dasaratha
Abstract : The plants of the genus &lsquo;Leucas&rsquo; have been found to be useful in various diseases. Leucas diffusa (LD) widely distributed throughout India as a weed in cultivated fields, wastelands &amp; roadsides. There is no scientific report published indicating utility of this plant. The present study was performed to evaluate the antioxidant and anti-inflammatory activities by using hydroxyl radical, reducing power &amp; hydrogen peroxide scavenging abilities and through acetic acid induced vascular permeability model in mice &amp; acetic acid induced colitis in rats significantly. LD (1000 mg/kg, p.o.) presented a significant anti-inflammatory activity towards acetic acid induced vascular permeability model in mice in comparison to Diclofenac sodium(10 mg/kg, s.c.) and acetic acid induced colitis in rats in comparison to 5-ASA. Our findings suggest that, LD contains potential antioxidant and anti-inflammatory compounds which will aid us to conduct bioactivity guided isolation &amp; characterization of leading compounds in due course. <br />

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