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Title : DELIVERY OF WATER-INSOLUBLE DRUGS: CAFFEINE MONOHYDRATE AND SALICYLIC ACID AS MICROCAPSULES USING IRVINGIA GUM AS THE COACERVATING AGENT
Authors : Uzondu, Akueyinwa Lovet Esther, Okor, Roland Sydney
Abstract : The potential of irvingia gum as a coacervating agent was investigated in the microencapsulation of caffeine and salicylic acid. Irvingia gum was produced according to the methods described by previous workers. Coacervation was achieved by adding ethanolic solution of the drug (6g in 8ml) to the gum mucilage (3g in 100ml of water): i.e, gum: drug ratio 1:2, and allowing to stand for 48h to form a sediment ( coacervate). Also prepared were gum: drug ratios: 1:1 and 2:1. Effects of composition, temperature and pH on coacervate yield and degree of drug entrapment were investigated. Tragacanth gum was used, as reference standard. 1:2 ratio gave the highest yield for both caffeine (78.5±0.02% w/w) and salicylic acid (79±0.00%w/w) coacervates. pH increase of gum mucilage (2.21 to 12.03) increased the yield of irvingia caffeine coacervate but decreased that of irvingia: salicylate coacervates. Raising the temperature (25-600C) decreased both coacervate yields. Both systems (with gum: drug ratio 1:2) gave the highest degree of drug  entrapment. This study, therefore, presents optimal condition for enhancement of yield and degree of drug entrapment in coacervation of poorly-water soluble drugs: caffeine and salicylic acid.

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