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Title : PREPARATION OF NANOPARTICLES OF CANDESARTAN CILEXETIL BY IONOTROPIC GELATION TECHNIQUE AND THEIR EVALUATION
Authors : Shilpa Bhilegaonkar, Ram Gaud
Abstract : Candesartan cilexetil is a poorly soluble antihypertensive agent with low bioavailability. It is a prodrug which converts into active drug candesartan with hydrolysis in GIT.Ion gelation technique is utilized for delivery of protein and peptide drug and involves formation of nanoparticles by means of electrostatic interactions between the positively charged chitosan chains and polyanions employed as cross linkers. The most extensively used polyanion is the tripolyphosphate (TPP). As chitosan is soluble in acidic pH and reduction in particle size was required to enhance solubility and dissolution of candesartan cilexetil, nanoparticles of candesartan cilexetil were prepared by ionotropic gelation technique and evaluated for particle size , surface morphology, saturation solubility and multimedia dissolution. The technique was found to be effective for candesartan cilexetil with particle size in the range of 324 nm with a smooth surface. Percentage entrapment efficiency was in between 45-54%. Rise in solubility and dissolution as compared to pure drug was seen with little slow release in acidic and buffer media.

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