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Title : PREPARATION AND COMPARITIVE EVAULATION OF NIZATIDINE LOADED SUPER POROUS FLOATING HYDROGELS
Authors : K.B.V. Yasaswi, Sowjanya Battu, V. Umamaheswara Rao
Abstract : The objective of the present investigation is to formulate Nizatidine loaded superporous floating hydrogel tablets. In the present study Nizatidine floating tablets were prepared by effervescence method using sodium bicarbonate as a gas generating agent. The tablets were formulated using direct compression technology by employing polymers like chitosan, carbopol 934p and ethyl cellulose. The prepared superporous floating hydrogel tablets were evaluated for pre compression, post compression and in-vitro drug release. The in-vitro drug release pattern of Nizatidine loaded superporus floating hydrogel tablets was fitted in different kinetic models which showed highest regression for zero order kinetics with higuchi’s type of drug release mechanism. Among all the formulations, F18 which is acombination of chitosan,carbopol 934p and ethyl cellulose was optimized based on desired sustained release time (18hrs) followed by acceptable swelling and floating properties.

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