||In the present study UV-spectrophotometric and RP-HPLC methods were validated for the simultaneous analysis of acetaminophen and caffeine in marketed tablets. The methods were validated in terms of linearity, accuracy (% Recovery), precision (inter day, intra day and reproducibility) and robustness. Both the methods were linear (R2 = 0.998-0.999) and accurate (% recovery was 99.29% - 100.19% for UV method and 99.14% - 100.25% for HPLC method). The method was also found precise (% RSD< 2%) and robust. Potency of five marketed brands was determined by both the methods and no statistically significant difference was noticed between the potency obtained from UV-spectrophotometric and RP-HPLC methods by paired t test at 5% significance level. Drug release from the marketed products complied compendia specification that indicates that test products are equivalent. Any one of the validated methods can be used for the analysis of acetaminophen and caffeine tablets.