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Title : DERMAL TOXICITY STUDY OF AN ANTIDERMATOPHYTIC OIL-MOISTENED DICHLOROMETHANE-METHANOL (1:1 V/V) STEM BARK EXTRACT OF POLYSCIAS FULVA HIERN (ARALIACEAE) IN GUINEA PIGS ANIMAL MODEL
Authors : Guy Sedar Singor Njateng, Donatien Gatsing, Raymond Simplice Mouokeu, Jules-Roger Kuiate
Abstract : Polyscias fulva, a medium size tree which grows in the tropical forests of West and Central Africa, is a popular medicinal plant used to treat malaria, mental illness, venereal infections, pulmonary tuberculosis as well as dermatoses. To the best of our knowledge there is no documented evidence corroborating its safety. Thus this work aimed to determine dermal toxicity profile of the antidermatophytic oil-moistened dichloromethane-methanol (1:1 v/v) stem bark extract of Polyscias fulva. Guinea pig (male and female) animal model was used for both acute and sub-acute dermal toxicity studies. For acute toxicity, single doses (0.5, 4.25 and 8 g/kg body weight) of oilmoistened plant extract were administered to animals while in sub-acute dermal toxicity, doses (13, 256.5 and 500 mg/kg bw) of plant extract were administered daily during 28 days. The possible toxic effect of the plant extract was assessed based on the animal behaviors, the organ morphology and histology, the hematological and biochemical parameters. The single and repeated dermal toxicity tests on guinea pigs did not show any overt sign of toxicity on growth patterns. The lethal dose fifty (LD50) of the oil-moistened extract was higher than 8000 mg/kg. Moreover, the hematological and biochemical parameters, liver and kidney histopathology analysis collectively indicate that dermal application of the oil-moistened extract from the stem bark of Polyscias fulva is not associated with any toxicologically relevant effects in neither male nor female guinea pigs. The overall results of this study indicate that the oil-moistened dichloromethane-methanol (1:1 v/v) stem bark extract of Polyscias fulva could provide satisfactory preclinical evidence of safety to launch a clinical trial on a standardized formulation of the plant extracts.

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