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Title : STAPHYLOCOCCUS AUREUS (MRSA) IN INTRA-ABDOMINAL INFECTIONS: RESISTANCE PATTERN AGAINST DIFFERENT ANTIBIOTICS
Authors : Samiullah Burki, Zeba Gul Burki, Izhar Ahmed, Javeid Iqbal
Abstract : Intra-abdominal infections (IAI’s) a common cause of sever sepsis in the world and is caused by methicillinresistant Staphylococcus aureus (MRSA), which include pancreatitis, appendicitis, peritonitis and cholecystitis. The aim of current work was to study resistance of MRSA against various antibiotics. A total of 14 clinical isolates of IAI’s patients were collected from public hospitals conformed using catalase and coagulase positive tests. Those isolates were evaluated for their resistance level against different antibacterial using agar dilution method. At concentration of 8 mg/l MRSA exhibited 100 % and 92.86 %sensitivity to linezolid and tobramycin while meropenem achieve this level at 128 mg/l (p<0.05) Tetracycline and cefuroxime give similar sensitivity levels against MRSA 128 mg/l and 8 mg/l .The mean sensitivity of MRSA at different concentrations of Linezolid was effective than levofloxacin while tobramycin also represent ~90 % mean sensitivity. MIC90 of linezolid and levofloxacin was ≥ 4mgl-1 and7mgl-1 respectively. Tobramycin and cefuroxime shows appropriate MIC’s of ≥ 6mg- 1 and 5.5mgl-1 (P<0.01).The finding suggest that potency of antimicrobials against multidrug resistant MRSA of IAI’s was linezolid> tobramycin >cefuroxime >levofloxacin>>…>Meropenem >tetracycline. IAI’s can be effectively manage with above study drugs.

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