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Title : EVALUATION OF IN-VITRO ANTI-INFLAMMATORY, THROMBOLYTIC AND CYTOTOXIC PROPERTIES OF LABLAB NIGER LEAVES
Authors : Md. Reyad-ul-Ferdous, Hasnin Rahman Jisha, Md. Golam Azam
Abstract : The present study was undertaken to investigate anti-inflammatory, thrombolytic and cytotoxic activities of methanol extracts of Lablab niger leaves and its different fractions. In-vitro anti-inflammatory activity of the L. niger leaves was evaluated by heat and hypotonic solution induced membrane stabilization method. Thrombolytic activity was evaluated using blood clot lysis model and cytotoxicity test was carried out by brine shrimp lethality bioassay. The crude methanolic extract and all tested fractions of L. niger leaves significantly (p< 0.005) protected erythrocyte membrane lysis comparable to standard aspirin, demonstrating its strong anti-inflammatory activity. In thrombolytic study, the crude methanolic extract and its different fractions demonstrated moderate to strong thrombolytic activity (25.62-40.88% lysis of human blood clot), in comparison to 66.75 % clot lysis by standard streptokinase. In the brine shrimp lethality bioassay, methanolic extract and its different fractions of L. niger leaves showed significant lethality with LC50 =value of 1.171-8.15 μg/mL, compared with vincristine sulphate (LC50=0.451 μg/mL). These finding indicate that L. niger leaves could be a potential source of natural anti-inflammatory, thrombolytic and cytotoxic agents.

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