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Title : Cytotoxicity Assay of Nickel and Cobalt (II) Complexes of 5-(4-Nitro Phenyl)-4-Amino-3-Mercapto Propenyl-1,2,4-Triazole on HepG2 Cell Line
Authors : Mahasin Alias, Ameena N. Seewan, Carolin Shakir, Farooq I. Mohammad
Abstract : Two new complexes with formula [M(NMP.TRZ)(H2O)3](NO3)2.3EtOH (where M is Ni and Co(II) ions respectively, NMP.TRZ is (5-(4-Nitro Phenyl)-4-Amino-3-Mercapto Propenyl-1,2,4-Triazole) have been synthesized by conventional method. These complexes have been characterized by spectroscopic methods such as (ultraviolet- visible and infrared), as well as to thermal gravimetric, metal analyses, microanalyses, conductivity, magnetic moment and molar ratio method. To measure the biologic activity and potential anticancer efficacy of these compounds, they have been compared with cisplatin on human hepatocarcinoma HepG2 cell lines in different eight concentrations (2000, 1000, 500, 250, 125, 62.5, 31.25 and 15.625 μg/ml) respectively, in the time of exposure 72 hrs. The results exhibit that the three prepared complexes i.e. ligand (NMP.TRZ) and its metal complexes have shown higher ratios cytotoxicities compared to cisplatin against HepG2 cell lines in most selected concentrations. Based on the obtained results of biological test, these compounds may be potentially being considered as good anticancer candidates for further pharmacological studies.

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