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Authors : Sylvie Lea Wansi, Idrice Kamtchouing, Jules Roger Kuiate, Telesphore Benoît Nguelefack, Hippolyte K. wabo, Albert Kamanyi
Abstract : Pentadesma butyracea Sabine (Clusiaceae) is a medicinal plant used in Cameroon to cure ailments such as gastrointestinal disorders. This study was aimed at investigating the antidiarrhoeal and antimicrobial activities of the methanolic extract from the stem bark of P. butyracea (MEPB). Plant extract was prepared by maceration in methanol. Its oral antidiarrhoeal effects were evaluated in vivo on castor oil (10ml/kg bw) and magnesium sulfate (3g/kg bw) induced diarrhea. Diarrheic rats were treated with 125, 250, and 500mg/kg extract or loperamide 2.5mg/kg. The frequency of defecation, the latency time and water content of stool were assessed. The broth microdilution method was used to evaluate the in vitro antibacterial activity against 10 bacterial strains: Enterococcus feacalis, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Klebsiella pneumonia, Shigella flexneri, Enterobacter cloacae, Staphylococcus epidermidis, Salmonella thiphymurium et Proteus mirabilis. In vivo antimicrobial activity of the extract was assessed using an S. flexneri-infected rat model. P. butyracea extract significantly and dose dependently increased the time of appearance of the first stools and decreased the frequency of defecation and the water content of stool. It also showed relatively good antimicrobial activity against all the tested microorganisms (MIC 64 – 256 µg/ml) and MBC (256 – 1024 µg/ml); with Enterococcus feacalis being the most sensitive. At dose 500 mg/ml, P. butyracea significantly reduced shigella flexneri density (80.37%). Results suggest that Pentadesma butyracea possesses antidiarrheic and antimicrobial properties and attest its usefulness in traditional treatment of gastrointestinal disorders such as diarrhea, and the treatment of some bacterial infections as shigellosis.

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