||The reaction of progesterone 1 with different aromatic aldehydes refluxed in absolute ethanol in the presence of
sodium hydroxide afforded new progesterone chalcone hybrids (2a-e). Chalcone progesterone 2b reacted with
(cyclohexyl amine, o-anisidine and p-toluidine) in boiling absolute ethanol to yield the corresponding adducts (3, 4
and 5). Treatment of 2b with (2-aminothiophenol) gave the adduct 6. Hetero-aryl chalcones (2d,e) were exposed to
UV lamp (125w) in the presence of benzene yielded cyclobutane derivatives (7a,b). Compound 2d,e were irradiated
in ethanol a pinacol dimeric products were obtained 8a,b. The antiviral of some newly products were examined.