||The modern era has witnessed development of alternate and successful routes of drug delivery system i.e. Transdermal Drug Delivery System (TDDS). In a broad sense, it includes all topically administered drug formulations intended to deliver the active ingredient into the general circulation. Increasing prevalence of diabetes is presently pushing strong demand for novel drug delivery devices. Most of the antidiabetic drugs today are available in injectable form through syringes, pens, pumps and needle-free devices. Today about 74% of drugs are taken orally and are found not to be as effective as desired. Innovations in drug delivery systems have not only enabled the successful implementation of many of these novel pharmaceuticals, but have also permitted the development of new medical treatments with existing drugs. The creation of TDDS has been one of the most important innovations. This article provides an overview on various techniques and new antidiabetic approaches of TDDS.