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Title : Evaluation of Antidepressant Activity of Bacopa Monnieri in Mice
Authors : Pabba Sindhu, Mukta N. Chowta, Nishith RS, Seema Rai, Akash Gadgade, Rajeshwari S
Abstract : This study was planned with the objective of evaluating antidepressant activity Bacopa monnieri (Brahmi), a traditional Ayurvedic medicine, in two experimental models of depression in mice. Adult Albino Mice (Swiss Strain) of either sex randomly assigned to four groups of six mice each. Group 1 received distilled water and group 2 received imipramine 10mg/kg orally. Group 3 & 4 received B. monnieri extract at a dose of 50mg/kg and 100mg/kg respectively (orally). Mice were subjected to forced swim test and tail suspension test. Drugs were given one hour before the experiment in acute study whereas for chronic study drugs were given for 10 days. The decrease in immobility period in the group pretreated with imipramine as compared to control was highly significant in both acute and chronic study with forced swim test. Comparison of both the doses of Bacopa monneiri with control group also showed very high statistical significance in acute as well as chronic study. In tail suspension test, the decrease in immobility period in the group pretreated with imipramine as compared to control was significant in both acute and chronic study. Comparison of Bacopa monneiri 50mg/kg with control group did not show statistical significance in acute study, but the significant difference was demonstrated in chronic study. Comparison of Bacopa monneiri 100mg/kg with control group also showed statistical significance in acute as well as chronic study. Bacopa monneiri has demonstrated significant antidepressant activity in both the models and the effect is dose dependent. Its antidepressant effect is comparable with imipramine especially at 100mg/kg dose.

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