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Title : In vivo studies of (Z)-1-benzhydryl-4- cinnamylpiperazines as anti-inflammatory and analgesics
Authors : S Shivaprakash, Anaxee Burman, Latha Diwakar and G. Chandrasekara Reddy
Abstract : Benzhydryl cinnamyl piperazine drugs such as cinnarizine, flunarizine and clocinizine are being used as antihistamines and as calcium channel antagonists but possess E-geometry. The present study was designed to evaluate and compare anti-inflammatory and analgesic activities of (Z)-1-benzhydryl-4- cinnamylpiperazine derivatives (2a-c) with their E counterparts in-vivo using Swiss-albino mice. The results of the present study revealed that the Z-isomers have showed moderate to significant analgesic and anti-inflammatory action in a dose dependent manner. However, Z-counterpart of flunarizine exhibited remarkable analgesic property and also showed prolonged antiinflammatory activity compared to flunarizine.

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