||Benzhydryl cinnamyl piperazine drugs such as cinnarizine, flunarizine and clocinizine are being used as
antihistamines and as calcium channel antagonists but possess E-geometry. The present study was designed to
evaluate and compare anti-inflammatory and analgesic activities of (Z)-1-benzhydryl-4- cinnamylpiperazine
derivatives (2a-c) with their E counterparts in-vivo using Swiss-albino mice. The results of the present study
revealed that the Z-isomers have showed moderate to significant analgesic and anti-inflammatory action in a dose
dependent manner. However, Z-counterpart of flunarizine exhibited remarkable analgesic property and also showed
prolonged antiinflammatory activity compared to flunarizine.