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Title : Formulation & evaluation of muccoadhesive buccal patches for delivery of atenolol
Authors : Neha krishnarth, Navneet verma, Basant Sharma
Abstract : Mucoadhesive buccal patches of Atenolol for local delivery of the drug to the oral cavity were formulated by Solvent casting technique. Mucoadhesive polymer, namely sodium carboxymethyl cellulose (NaCMC) of different grade were incorporated into the patches to modify their mucoadhesive properties as well as the rate of drug release, using glycerol as plasticizer. Different concentrations of polymer were used for the preparation of patches. The patches were evaluated on the basis of their physical characteristics like surface pH, folding endurance, mucoadhesive performance, and release rate. The in-vitro drug release was carried out in Franz diffusion cell, with commercially available dialysis membrane. Formulation P-10 (10 % Sodium carboxy Methyl Cellulose (NaCMC), 5 % glycerol and 2 % Atenolol) showed sustained release upto 10 hours.

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