||The study was aimed to assess the pharmaceutical equivalence of some losartan potassium tablets of different
manufacturers marketed in Bangladesh using in vitro dissolution study. The dissolution was carried out using the
apparatus II according to USP guidelines. Other general quality assessment tests like hardness, friability,
disintegration time were also determined. All brands complied with the official specification for hardness, friability
and disintegration time. The dissolution profiles showed inter brand and intra brand variability. All samples attained
more than 85% dissolution within 30 minutes. The results were subjected to statistical analysis to compare the
dissolution profiles. A model independent approach of similarity factor (f2) was employed. The data indicated that
only two brands may be used interchangeably.