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Title : THE IN VITRO PHARMACEUTICAL EQUIVALENCE STUDIES OF LOSARTAN TABLETS OF DIFFERENT MANUFACTURERS AVAILABLE IN BANGLADESH
Authors : Rehana Begum, Md. Zakir Sultan, Asma Rahman, Md. Akter Hossain and Md. Shah Amran
Abstract : The study was aimed to assess the pharmaceutical equivalence of some losartan potassium tablets of different manufacturers marketed in Bangladesh using in vitro dissolution study. The dissolution was carried out using the apparatus II according to USP guidelines. Other general quality assessment tests like hardness, friability, disintegration time were also determined. All brands complied with the official specification for hardness, friability and disintegration time. The dissolution profiles showed inter brand and intra brand variability. All samples attained more than 85% dissolution within 30 minutes. The results were subjected to statistical analysis to compare the dissolution profiles. A model independent approach of similarity factor (f2) was employed. The data indicated that only two brands may be used interchangeably.

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