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Title : PRECLINICAL LIPID PROFILE STUDIES OF A CLASSICAL AYURVEDIC PREPARATION “ARJUNARISTA” AFTER CHRONIC ADMINISTRATION TO MALE SPRAGUE-DAWLEY RATS
Authors : Marjana Khalil, Swagata Sarker Lopa, Md. Rakib Hasan, Md. Mahmudur Rahman Mamun, Paritosh Chakma, Arjyabrata Sarkar, Mohammed Motaher Hossain Chowdhury and M. S. K. Choudhuri
Abstract : Arjunarista (RJN) is an Ayurvedic preparation used as a traditional medicine in the south Asian countries for the treatment of cardiac diseases. We were eager to know the effect of chronic administration of RJN on the lipid profile test. To find out the effect of chronic administration of RJN on the lipid profile it was administered chronically to the male Sprague-Dawley rats at a dose of 40 ml/Kg. After 28 days of chronic administration of the RJN preparation, the following effects on the lipid profile were noted. There was a very highly significant increase in LDL Cholesterol (p=0.001). A very highly significant (0.001) decrease was noticed in triglyceride (TG), VLDL-C & HDL-C level; thus leading to a statistically very highly significant (p=0.001) increase in Cardiac Risk Ratio (CRR) (TC/HDL-C), Castelli’s Risk Index-II (CRI-II) (HDL-C/LDL-C) and Atherogenic Coefficient (AC) [(TC/HDL-C)/HDL-C)], but a statistically significant (p=0.033) decrease in case of Atherogenic Index of Plasma (AIP) (log (TG/HDL-C)).

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