||Medical plants have a wide range of pharmacological activities such as anti-inflammatory, immunological, antiviral, hypoglycemic, antifungal, antihepatic, antiphlogistic cardiovascular and central nervous effect especially in developing countries where resources are meager. About 80% of the remote area populations rely on the traditional medicines for their health. In literature approximately 500 plants with medicinal use are mentioned and around 800 plants have been used in indigenous systems of medicine. Because of side effect of synthetic drugs, there is an increasing interest towards natural product remedies with a basic approach towards the nature. The inflammatory drug from plants in present clinical use and their similar mechanism of action of medicinal components are preferred mainly due to low cost and lesser side effects. A number of side effects like gastrointestinal bleeding, mucosal erosion, hepatotoxicity, renal toxicity and nephropathy are associated with the use of Anti-inflammatory drugs. Cycoloxygenase-1 enzyme is present throughout the body and their functions is to maintains the normal gastric mucosa and influencing renal blood flow and platelet aggregation and Cyclooxygenase-2 mediates inflammatory responses. Non-steroidal anti-inflammatory drugs inhibit both enzymes; inhibition of Cox2 is directly implicated in ameliorating inflammation, whereas the inhibition of cyclooxygenase - 1 causes adverse effects in the gastrointestinal tract. Meanwhile, in order to avoid from side effect, there are development and introduction of new antipyretic, analgesic and anti-inflammatory agents that compete with Non-steroidal anti-inflammatory drug. The use of natural remedies for the treatment of inflammatory and painful condition has long history starting with Ayurvedic treatment, extends to the European and other systems of traditional medicines. The present review focus on the some of the medicinal plants and their medicinal uses which have been shown experimentally. The profiles presented include information about the scientific name, family, methodology used and the degree of anti-inflammatory activity. WHO has pointed out this prevention of inflammatory diseases and its complications is not only a major challenge for the future, but essential if health for all is to attain. Therefore, in recent years, considerable attention has been directed towards identification of plants with anti-inflammatory activity that may be used for human consumption.