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Title : PRECLINICAL ANEMIA PANEL STUDIES OF “ROHITAKARISTA” AFTER CHRONIC ADMINISTRATION TO MALE SPRAGUE-DAWLEY RATS
Authors : K. N. Roy Niyati, Md. Rakib Hasan, Swagata Sarker Lopa, Ishtiaque Ahmed Chowdhury, Marjana Khalil, Maksud Hassan Binoy, M Salahuddin Bhuiya and M. S. K. Choudhuri
Abstract : <div style="text-align: justify">Rohitakarista (RHT) is an Ayurvedic preparation used as a traditional medicine in the South Asian countries for the treatment of liver disorders, splenomegaly and other spleen related problems. The effect of chronic administration of Rohitakarista on the hematological parameters and serum iron profile was studied in this experiment. The acute toxicity test of RHT recorded no death, even at the highest dose of 80 ml/Kg body weight. The animals were divided into two groups. The first group was given RHT preparation at a dose of 40 ml/Kg body weight for 28 days while the second group that served as the control received water for the same period. After 28 days chronic administration of the RHT preparation to the male Sprague-Dawley rats the following hematological changes were noted. There were a statistically significant decrease in total red blood cell (RBC) count (p=0.03) and Hemoglobin content of the blood (p=0.04) whereas a highly significant decrease (p=0.01) in case of Hematocrit level of the blood. The erythrocytic indices such as mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) and red cell volume distribution width (RDW) did not change significantly. A significant decrease was noted in case of serum Iron level (p=0.044) whereas a statistically significant (p=0.039) increase was noticed in serum Ferritin level.</div>

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