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Title : INCLUSION COMPLEXATION BY CYCLODEXTRIN : A NOVEL APPROACH TO IMPROVE SOLUBILITY AND BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUG
Authors : Bhopate Sapana B, Dhole Shashikant N
Abstract : <div style="text-align: justify">Cyclodextrins are cyclic oligosaccharides which have recently been recognized as useful pharmaceutical excipients. The outer surface of these doughnut-shaped molecules is hydrophilic, but they possess an axial open cavity, which is of hydrophobic character and capable of including other apolar molecules in case of geometric compatibility. This is the essence of molecular encapsulation by inclusion complex formation. Low solubility compounds show dissolution rate limited absorption and hence poor absorption, distribution and target organ delivery. Improvement of aqueous solubility in such a case is valuable goal to improve therapeutic efficacy. Complexation with CDs by different methods like physical mixing, kneading, spray drying, freeze drying, etc., has been reported to enhance the solubility, dissolution rate and bioavability of poorly water soluble drugs. This review aims to assess the use of cyclodextrins as complexing agents to enhance the solubility of poorly soluble drugs and hence to resolve the many issues associated with developing and commercializing poorly water soluble drugs.&nbsp;</div>

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