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Title : PREPARATION, CHARACTERIZATION AND IN VITRO - IN VIVO EVALUATION OF GLICLAZIDE LOADED POLYMERIC MICROSPHERES
Authors : Mohammad Sofiqur Rahman, Amit Kumar Chaurasiya, Sazia Afreen Rahee, Ikramul Hasan, Mohammad Shahriar, Mohiuddin Ahmed Bhuiyan and Md. Selim Reza
Abstract : <div style="text-align: justify">Type 2 diabetes mellitus is a heterogeneous disease which involves both defective insulin secretion and peripheral insulin resistance. Despite the availability of other agents for treatment of type 2 diabetes mellitus gliclazide, is preferred in diabetic therapy because of its selective inhibitory activity towards pancreatic K+-ATP channels, antioxidant property, low incidence of producing severe hypoglycemia and other haemobiological effects. In the present study gliclazide microspheres were prepared using combination of Ethyl cellulose (20 cps), Methocel K4M, Methocel K15M and Eudragit-RSPO by solvent evaporation method. They were evaluated for their microencapsulation efficiency, in vitro drug release, and surface morphology, compatibility between drug and polymers and in vivo anti-diabetic study. The microspheres were almost spherical and slightly rough. The encapsulation efficiency was in the range of 68-92%. The drug release was also found to be slow which extended for almost 8 hours. FTIR and DSC analysis indicated the good compatibility between the dug and polymers. In vivo study of the gliclazide microspheres in albino rats demonstrated significant antidiabetic effect of gliclazide. In case of gliclazide microspheres the hypoglycemic effect obtained was for more than 10 hours whereas pure gliclazide produce antidiabetic effect for only 4-5 hours suggesting that microspheres of gliclazide may be a potential candidate for safe and effective controlled drug delivery for the treatment of type 2 diabetes mellitus.</div><div style="text-align: justify"><br /></div>

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