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Title : SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF PYRIMIDINE DERIVATIVES
Authors : Ayushi Uniyal, Alka N. Choudhary, Preeti Kothiyal
Abstract : A series of 3-amino-4,6-diphenyl-3,4-dihydro-1H-pyrimidine-2-thione derivatives  have been synthesized by cyclization of substituted chalcones with thiosemicarbazide. The structures of all newly synthesized compounds were confirmed  by FT- IR, 1H NMR and Mass spectral analysis. The synthesized compounds were screened for  antibacterial activity (500µg/ml) concentration level by disc diffusion method against (Gram negative) Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia.

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