||Nanopatch is a modern technique which designed to target the network of immunologic antigen presenting cells in the dermis and epidermis layers under the skin to enhance the efficacy of vaccination. Nano patch contains the micro sized needles that are painlessly penetrating and the nano-formulated medicines, drugs and vaccines directly go to the immune system. The comparative studies outline that there is increased stability, conventional route, easy to use and also the wide range of vaccines can be used. Nano patch one day will be self-administered or given by a non-medical person, which reduces the administration cost and also relieve from burden on health care professionals. Receiving vaccines from doctor’s office or health clinic may soon be outdated.