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Title : TOXICOLOGICAL STUDIES OF AN AYURVEDIC MEDICINE (BRIHOT CHANDRODOY MAKARDHWAJ) USED AS REJUVENATOR
Authors : Tahmina Akter Sony, Md. Rakib Hasan, Mst. Reshma Khatun, Md. Mamun Sikder, Mustari Hossain, Shemonty Hasan, Massnoon Ali, M. S. K. Choudhuri
Abstract : Brihot Chandrodoy Makardhwaj (BCM) is an Ayurvedic preparation used as a traditional medicine in the old age in the rural population. To find out the toxicological characteristic of BCM, it was administered chronically to the male Sprague-Dawley rats at a dose of 100 mg/kg. After 32 days chronic administration of the BCM preparation the following toxicological changes were noted. All throughout the experimental period the BCM treated animals were always maintaining insignificant increase in body weight in the body weight study. There is a statistically significant increase in the relative percent weight of the male rat heart (p=0.024) and kidney (p=0.032). There is a statistically highly significant increase in the absolute weight of the male rat spleen (p=0.009) and relative percent weight of the spleen (p=0.003). There is also a statistically significant (p=0.028) increase in the absolute weight of the rat testis.

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