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Title : VDR- A GENE MARKER TO PREDICT THE TB RESPONSIVENESS OF HUMAN WITH SPECIAL REFERENCE TO INDIAN POPULATION
Authors : Jamsheer A.M, Umesh C.V, Prasad M. Alex, Krishnan Namboori P.K.
Abstract : Single-nucleotide polymorphisms (SNPs) have been reported as the genetic signature for proneness of a disease. In the present study, 19 deleterious SNPs have been identified from human VDR gene and can be used as the genetic signature to assess the proneness of attack by mycobacterium tuberculosis. All the SNPs are found to be cis type supporting the possibility of methylation and variation. The SNP rs10735810, has been identified as the common SNP present in major populations of India and can be considered as the genetic signature behind the attack of TB.

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