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Title : SCREENING OF IN-VITRO ANTIOXIDANT, BRINE SHRIMP LETHALITY BIOASSAY AND ANTIMICROBIAL ACTIVITIES OF EXTRACTS OF BRIDELIA RETUSA (L.) SPRENG. FRUIT
Authors : Tufikul Islam, Mohammad Raquibul Hasan, Aumit Roy, Md. Shafiqul Islam, Md. Afaz Uddin, Md. Ariful Islam, Md. Nuruzzaman Neon, Md. Sohel Rana
Abstract : The objective of present study was to investigate the antioxidant, brine shrimp lethality and antimicrobial activities of Bridelia retusa (L.) Spreng. fruit using n-hexane, ethyl acetate and methanol extracts. Several methods were used for assessing antioxidant activity. In total phenol content determination methanolic extract showed highest value of 134.5 mg/g as Gallic Acid Equivalent (GAE). N-hexane extract showed highest total flavonoid content with 60.50 Plus or Minus 4.95 mg/gm as Quarcetin Equivalent (QE). Methanolic extract showed highest tannin content with 652.50 Plus or Minus 3.53 mg/gm as Tannic Acid Equivalent (TAE) and total anti-oxidant capacity with 236.00 Plus or Minus 36.78 mg/gm as Ascorbic Acid Equivalent (AAE). Methanolic extracts showed good DPPH free radical scavenging activity with IC50 of 168.757 mg/mL. Ethyl acetate extract showed highest reducing capacity in CUPRAC test. Methanolic extracts showed good cytotoxic activity with IC50 value of 20 mg/ml in brine shrimp lethality bioassay. In antimicrobial assay extracts showed poor activity. Further studies are needed to isolate active compounds.

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