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Authors : Sadia Shakeel, Zeeshan Ahmed Sheikh, Somia Gul, Khan Usmanghani
Abstract : The present study was conducted to develop and evaluate the quality control parameters of polyherbal Entoban capsules to reassure the safety and efficacy of developed dosage form. The flow property of powdered extract was evaluated by determining bulk density, tap density, Carr's index, Hausner's ratio and angle of repose. Various physicochemical parameters including weight variation and disintegration time were calculated. Alkaloids, tanning agents and microbial limit of the polyherbal formulation were also evaluated. The powder showed good flow property. Average weight of 20 capsules was between 450 mg and 550 mg (with a mean of 506 mg Plus or Minus 10%). The maximum time for disintegration was 6 min. Both the alkaloids and tanning agents were within the specified limits. The developed formulation was in compliance of the permissible microbial limits. In the present study, the developed Entoban capsules were consistent with identity, quality, and purity specifications. So it can be concluded that developed formulation would provide an opportunity to validate its traditional claim regarding its therapeutic efficacy.

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