||This study has assessed the resistance pattern of common respiratory pathogens among the hospitalized ICUs patients. A total number of 51 clinical samples were collected of which 33 (64.71%) were from male and 18 (35.29%) were from female. Out of 51 samples, 45 (88.24%) samples yielded growth while no bacterial pathogen was isolated from rest 6 (11.76%) samples. The common infecting organisms isolated in this study were Staphylococcus aureus (n=27, 36.98%) and Pseudomonas aeruginosa (n=27, 36.98%), followed by Staphylococcus epidermidis (n=10, 13.69%), Salmonela enterica (n=5, 6.85%), Serrata marcescens (n=1, 1.37%), Klebsiella pneumoniae (n=1, 1.37%), Staphylococcus saprophyticus (n=1, 1.37%), Enterobacter aerogenes (n=1, 1.37%). Most of the isolates were 100% resistant to Penicillin, Ceftazidime, Ceftriaxone, Tetracycline, Cotrimoxazole and Piperacillin. Pseudomonas aeruginosa and Staphylococcus aureus show good sensitivity to all of the examined antibiotics. More specifically, Pseudomonas aeruginosa showed 100% sensitivity to Levofloxacin, Nalidixic acid, Cefotaxim, Piperacillin and Ceftriaxone.